Current approaches to development of contrast agents for MRI diagnostics

Development of 153Sm-DTPA-SPION as a theranostic dual contrast agents in SPECT/MRI

Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION: ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column...

Contrast agents for hepatic MRI

Liver specific contrast media (LSCM) can be subdivided according to different modalities of hepatic distribution: exclusive distribution to the hepatocellular compartment can be obtained using CM which accumulate within the hepatocytes after slow infusion; other CM demonstrate combined perfusion and hepatocyte-selective properties, with an initial distribution to the vascular-interstitial compa...

Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents.

Magnetic Resonance Imaging (MRI) methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents (CAs), capable...

Development of Gd@C60 Based MRI Contrast Enhancing Agents

Inorganic Nanoparticles for MRI Contrast Agents

O G Inorganic Nanoparticles for MRI Contrast Agents R E S By Hyon Bin Na, In Chan Song, and Taeghwan Hyeon* S R E P O R T Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI) contrast agents due to their unique properties, such as large surface area and efficient contrasting effect. Since the first use of superparamagnetic iron oxide (SPIO) as a liver contrast agen...